Version 5.4
Homo sapiens Gene: NACA
Summary
InnateDB Gene IDBG-41511.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NACA
Gene Name nascent polypeptide-associated complex alpha subunit
Synonyms NACA1; skNAC
Species Homo sapiens
Ensembl Gene ENSG00000196531
Encoded Proteins
IDBP-41513
nascent polypeptide-associated complex alpha subunit
IDBP-242696
nascent polypeptide-associated complex alpha subunit
IDBP-378222
nascent polypeptide-associated complex alpha subunit
IDBP-592361
nascent polypeptide-associated complex alpha subunit
IDBP-591981
nascent polypeptide-associated complex alpha subunit
IDBP-588705
nascent polypeptide-associated complex alpha subunit
IDBP-598632
nascent polypeptide-associated complex alpha subunit
IDBP-587824
nascent polypeptide-associated complex alpha subunit
IDBP-596069
nascent polypeptide-associated complex alpha subunit
IDBP-595066
nascent polypeptide-associated complex alpha subunit
IDBP-593137
nascent polypeptide-associated complex alpha subunit
IDBP-591001
nascent polypeptide-associated complex alpha subunit
IDBP-584212
nascent polypeptide-associated complex alpha subunit
IDBP-585744
nascent polypeptide-associated complex alpha subunit
IDBP-598817
nascent polypeptide-associated complex alpha subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). NAC binds to nascent proteins as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. However, nascent proteins with an exposed signal peptide will not be bound by the encoded protein, enabling them to bind the SRP and enter the secretory pathway. This protein has been determined to be an IgE autoantigen in atopic dermatitis patients. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56712428-56731628
Strand Reverse strand
Band q13.3
Transcripts
ENST00000356769 ENSP00000349212
ENST00000393891 ENSP00000377469
ENST00000454682 ENSP00000403817
ENST00000550920 ENSP00000448039
ENST00000550952 ENSP00000448035
ENST00000552540 ENSP00000447821
ENST00000548386
ENST00000548563 ENSP00000447705
ENST00000546392 ENSP00000446801
ENST00000547914 ENSP00000446745
ENST00000546410
ENST00000549259 ENSP00000447133
ENST00000551775
ENST00000552055 ENSP00000450383
ENST00000546862 ENSP00000446933
ENST00000549855 ENSP00000447764
ENST00000551793
ENST00000551520
ENST00000550343
ENST00000548084 ENSP00000447207
ENST00000546917 ENSP00000447666
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 40 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0017025 TBP-class protein binding
Biological Process
GO:0003231 cardiac ventricle development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006412 translation
GO:0010664 negative regulation of striated muscle cell apoptotic process
GO:0015031 protein transport
GO:0016032 viral process
GO:0043403 skeletal muscle tissue regeneration
GO:0048633 positive regulation of skeletal muscle tissue growth
GO:0048742 regulation of skeletal muscle fiber development
GO:0061384 heart trabecula morphogenesis
GO:1901227 negative regulation of transcription from RNA polymerase II promoter involved in heart development
GO:1901228 positive regulation of transcription from RNA polymerase II promoter involved in heart development
GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005854 nascent polypeptide-associated complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000061315
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.505735 Hs.732910
RefSeq NM_001113202 NM_001113203 XM_006719412 XM_006719413 XM_006719414 XM_006719415 XM_006719421
HUGO
OMIM
CCDS CCDS31837 CCDS44925
HPRD 03137
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca