Homo sapiens Gene: PRKX
Summary
InnateDB Gene IDBG-41523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKX
Gene Name protein kinase, X-linked
Synonyms PKX1;
Species Homo sapiens
Ensembl Gene ENSG00000183943
Encoded Proteins
protein kinase, X-linked
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
MAP3K7 (TAK1) Ser412 phosphorylation is regulated by PRKACA and PRKX, and is essential for proper signalling, as well as proinflammatory cytokine induction by TLR/IL-1R activation.
Entrez Gene
Summary This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:3604370-3713608
Strand Reverse strand
Band p22.33
Transcripts
ENST00000262848 ENSP00000262848
ENST00000425240
ENST00000462736
ENST00000496648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001525 angiogenesis
GO:0001935 endothelial cell proliferation
GO:0006468 protein phosphorylation
GO:0007155 cell adhesion
GO:0018105 peptidyl-serine phosphorylation
GO:0030099 myeloid cell differentiation
GO:0030155 regulation of cell adhesion
GO:0030334 regulation of cell migration
GO:0031589 cell-substrate adhesion
GO:0043542 endothelial cell migration
GO:0045087 innate immune response (InnateDB)
GO:0046777 protein autophosphorylation
GO:0060562 epithelial tube morphogenesis
GO:0060993 kidney morphogenesis
GO:2000696 regulation of epithelial cell differentiation involved in kidney development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
MAPK signaling pathway pathway
Calcium signaling pathway pathway
Chemokine signaling pathway pathway
Oocyte meiosis pathway
Apoptosis pathway
Vascular smooth muscle contraction pathway
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Gap junction pathway
Long-term potentiation pathway
Olfactory transduction pathway
Taste transduction pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Melanogenesis pathway
Vasopressin-regulated water reabsorption pathway
Salivary secretion pathway
Gastric acid secretion pathway
Bile secretion pathway
Parkinson's disease pathway
Prion diseases pathway
Vibrio cholerae infection pathway
Amoebiasis pathway
Dilated cardiomyopathy pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P51817
TrEMBL A0A024RBU5
UniProt Splice Variant
Entrez Gene 5613
UniGene Hs.390788 Hs.619481
RefSeq NM_005044 XM_005274560
HUGO HGNC:9441
OMIM 300083
CCDS CCDS14125
HPRD 02097
IMGT
EMBL BC041073 CH471074 X85545
GenPept AAH41073 CAA59733 EAW98727 EAW98728
RNA Seq Atlas 5613