InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRKX

Summary

InnateDB Protein

IDBP-41525.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKX

Protein Name

protein kinase, X-linked

Synonyms

PKX1;

Species

Homo sapiens

Ensembl Protein

ENSP00000262848

InnateDB Gene

IDBG-41523 (PRKX)

Protein Structure

UniProt Annotation

Function

Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. {ECO:0000269PubMed:12082174, ECO:0000269PubMed:16236808, ECO:0000269PubMed:16491121, ECO:0000269PubMed:17980165, ECO:0000269PubMed:19367327, ECO:0000269PubMed:21684272, ECO:0000269PubMed:9860982}.

Subcellular Localization

Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation.

Disease Associations

Note=A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.

Tissue Specificity

Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982. {ECO:0000269PubMed:15879576, ECO:0000269PubMed:16236808, ECO:0000269PubMed:7633447, ECO:0000269PubMed:9860982}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004691	cAMP-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0001935	endothelial cell proliferation
GO:0006468	protein phosphorylation
GO:0007155	cell adhesion
GO:0018105	peptidyl-serine phosphorylation
GO:0030099	myeloid cell differentiation
GO:0030155	regulation of cell adhesion
GO:0030334	regulation of cell migration
GO:0031589	cell-substrate adhesion
GO:0043542	endothelial cell migration
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation
GO:0060562	epithelial tube morphogenesis
GO:0060993	kidney morphogenesis
GO:2000696	regulation of epithelial cell differentiation involved in kidney development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt