InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCNE1

Summary

InnateDB Gene

IDBG-41865.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNE1

Gene Name

cyclin E1

Synonyms

CCNE

Species

Homo sapiens

Ensembl Gene

ENSG00000105173

Encoded Proteins

IDBP-41867

cyclin E1

IDBP-41869

cyclin E1

IDBP-376978

cyclin E1

IDBP-764480

IDBP-765180

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:29811898-29824308

Strand

Forward strand

Band

q12

Transcripts

ENST00000262643	ENSP00000262643
ENST00000357943	ENSP00000350625
ENST00000444983	ENSP00000410179
ENST00000576532	ENSP00000460881
ENST00000575243	ENSP00000459024
ENST00000574121
ENST00000586912

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 116 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	116 [view]
Protein-Protein	103 [view]
Protein-DNA	13 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019901	protein kinase binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006270	DNA replication initiation
GO:0006468	protein phosphorylation
GO:0016055	Wnt signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045859	regulation of protein kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051301	cell division
GO:0051726	regulation of cell cycle