InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCNE1

Summary

InnateDB Protein

IDBP-41867.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNE1

Protein Name

cyclin E1

Synonyms

CCNE;

Species

Homo sapiens

Ensembl Protein

ENSP00000262643

InnateDB Gene

IDBG-41865 (CCNE1)

Protein Structure

UniProt Annotation

Function

Essential for the control of the cell cycle at the G1/S (start) transition. {ECO:0000269PubMed:7739542}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:7739542}.

Disease Associations

Tissue Specificity

Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. {ECO:0000269PubMed:9840943}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 116 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	116 [view]
Protein-Protein	103 [view]
Protein-DNA	13 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019901	protein kinase binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006270	DNA replication initiation
GO:0006468	protein phosphorylation
GO:0016055	Wnt signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045859	regulation of protein kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051301	cell division
GO:0051726	regulation of cell cycle