Version 5.4
Homo sapiens Gene: DCT
Summary
InnateDB Gene IDBG-41926.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCT
Gene Name dopachrome tautomerase
Synonyms TRP-2; TYRP2
Species Homo sapiens
Ensembl Gene ENSG00000080166
Encoded Proteins
IDBP-41928
dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
IDBP-371713
dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
IDBP-591291
dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 13:94436808-94479682
Strand Reverse strand
Band q32.1
Transcripts
ENST00000377028 ENSP00000366227
ENST00000446125 ENSP00000392762
ENST00000483392 ENSP00000431275
ENST00000490854
ENST00000472871
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004167 dopachrome isomerase activity
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0002052 positive regulation of neuroblast proliferation
GO:0006583 melanin biosynthetic process from tyrosine
GO:0008152 metabolic process
GO:0008544 epidermis development
GO:0021847 ventricular zone neuroblast division
GO:0042438 melanin biosynthetic process
GO:0043473 pigmentation
GO:0048066 developmental pigmentation
GO:0048468 cell development
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016021 integral component of membrane
GO:0033162 melanosome membrane
GO:0042470 melanosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022129
View Gene Order
ENSBTAG00000002300
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00350
Tyrosine metabolism pathway
hsa04916
Melanogenesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.301865
RefSeq NM_001129889 NM_001922
HUGO
OMIM
CCDS CCDS45060 CCDS9470
HPRD 01864
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca