InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FGG

Summary

InnateDB Gene

IDBG-42165.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGG

Gene Name

fibrinogen gamma chain

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000171557

Encoded Proteins

IDBP-42169

fibrinogen gamma chain

IDBP-242764

fibrinogen gamma chain

IDBP-295189

fibrinogen gamma chain

IDBP-295187

fibrinogen gamma chain

IDBP-295186

fibrinogen gamma chain

IDBP-379099

fibrinogen gamma chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:154604134-154612967

Strand

Reverse strand

Band

q32.1

Transcripts

ENST00000336098	ENSP00000336829
ENST00000393846	ENSP00000377429
ENST00000404648	ENSP00000384860
ENST00000405164	ENSP00000384101
ENST00000407946	ENSP00000384552
ENST00000443553	ENSP00000407562
ENST00000492082
ENST00000465913
ENST00000464532
ENST00000473393
ENST00000465336
ENST00000484695

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	20 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005198	structural molecule activity
GO:0030674	protein binding, bridging
GO:0046872	metal ion binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002576	platelet degranulation
GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0034116	positive regulation of heterotypic cell-cell adhesion
GO:0043623	cellular protein complex assembly
GO:0045907	positive regulation of vasoconstriction
GO:0045921	positive regulation of exocytosis
GO:0050714	positive regulation of protein secretion
GO:0051258	protein polymerization
GO:0051592	response to calcium ion
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070527	platelet aggregation
GO:0090277	positive regulation of peptide hormone secretion
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005577	fibrinogen complex
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0031091	platelet alpha granule
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle