InnateDB Protein
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IDBP-295189.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FGG
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Protein Name
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fibrinogen gamma chain
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000384860
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InnateDB Gene
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IDBG-42165 (FGG)
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Protein Structure
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Function |
Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
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Subcellular Localization |
Secreted.
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Disease Associations |
Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=The disease is caused by mutations affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
24
[view]
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Protein-Protein |
20
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002181
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR012290
Fibrinogen, alpha/beta/gamma chain, coiled coil domain
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PFAM |
PF00147
PF08702
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PRINTS |
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PIRSF |
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SMART |
SM00186
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TIGRFAMs |
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Modification |
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SwissProt |
P02679
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PhosphoSite |
PhosphoSite-P02679
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TrEMBL |
D3DP16
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UniProt Splice Variant |
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Entrez Gene |
2266
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UniGene |
Hs.727584
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RefSeq |
NP_000500
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HUGO |
HGNC:3694
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OMIM |
134850
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CCDS |
CCDS47153
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HPRD |
00621
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IMGT |
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EMBL |
AC107385
AF118092
AF350254
AK289422
AK290824
BC007044
BC021674
BT007081
CH471056
K02569
M10014
X00086
X51473
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GenPept |
AAA52430
AAA52431
AAB59530
AAB59531
AAF22036
AAH07044
AAH21674
AAK19751
AAK19752
AAP35744
BAF82111
BAF83513
CAA24944
CAA35837
EAX04905
EAX04912
EAX04917
EAX04918
EAX04919
EAX04923
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