InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LRP1

Summary

InnateDB Gene

IDBG-42176.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRP1

Gene Name

low density lipoprotein receptor-related protein 1

Synonyms

A2MR; APOER; APR; CD91; IGFBP3R; LRP; LRP1A; TGFBR5

Species

Homo sapiens

Ensembl Gene

ENSG00000123384

Encoded Proteins

IDBP-42178

low density lipoprotein receptor-related protein 1

IDBP-42180

low density lipoprotein receptor-related protein 1

IDBP-602562

low density lipoprotein receptor-related protein 1

IDBP-585153

low density lipoprotein receptor-related protein 1

IDBP-593833

low density lipoprotein receptor-related protein 1

IDBP-600381

low density lipoprotein receptor-related protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:57128493-57213351

Strand

Forward strand

Band

q13.3

Transcripts

ENST00000338962	ENSP00000341264
ENST00000243077	ENSP00000243077
ENST00000451724
ENST00000553277	ENSP00000451449
ENST00000554174	ENSP00000451737
ENST00000556830
ENST00000553446
ENST00000554118	ENSP00000451622
ENST00000555941
ENST00000555124	ENSP00000451012
ENST00000556247
ENST00000556356

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	76 [view]
Protein-Protein	76 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004872	receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0034185	apolipoprotein binding
GO:0042954	lipoprotein transporter activity
GO:0044822	poly(A) RNA binding
GO:0070325	lipoprotein particle receptor binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007568	aging
GO:0007603	phototransduction, visible light
GO:0008203	cholesterol metabolic process
GO:0008283	cell proliferation
GO:0010875	positive regulation of cholesterol efflux
GO:0014912	negative regulation of smooth muscle cell migration
GO:0030178	negative regulation of Wnt signaling pathway
GO:0032370	positive regulation of lipid transport
GO:0032374	regulation of cholesterol transport
GO:0032429	regulation of phospholipase A2 activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0035909	aorta morphogenesis
GO:0042157	lipoprotein metabolic process
GO:0042953	lipoprotein transport
GO:0043277	apoptotic cell clearance
GO:0043524	negative regulation of neuron apoptotic process
GO:0051222	positive regulation of protein transport
GO:0097242	beta-amyloid clearance
GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005905	coated pit
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030136	clathrin-coated vesicle
GO:0030425	dendrite
GO:0030666	endocytic vesicle membrane
GO:0043025	neuronal cell body
GO:0043235	receptor complex