Homo sapiens Gene: LRP1
Summary
InnateDB Gene IDBG-42176.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRP1
Gene Name low density lipoprotein receptor-related protein 1
Synonyms A2MR; APOER; APR; CD91; IGFBP3R; LRP; LRP1A; TGFBR5;
Species Homo sapiens
Ensembl Gene ENSG00000123384
Encoded Proteins
low density lipoprotein receptor-related protein 1
low density lipoprotein receptor-related protein 1
low density lipoprotein receptor-related protein 1
low density lipoprotein receptor-related protein 1
low density lipoprotein receptor-related protein 1
low density lipoprotein receptor-related protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:57128493-57213351
Strand Forward strand
Band q13.3
Transcripts
ENST00000338962 ENSP00000341264
ENST00000243077 ENSP00000243077
ENST00000451724
ENST00000553277 ENSP00000451449
ENST00000554174 ENSP00000451737
ENST00000556830
ENST00000553446
ENST00000554118 ENSP00000451622
ENST00000555941
ENST00000555124 ENSP00000451012
ENST00000556247
ENST00000556356
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 76 [view]
Protein-Protein 76 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004872 receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0034185 apolipoprotein binding
GO:0042954 lipoprotein transporter activity
GO:0044822 poly(A) RNA binding
GO:0070325 lipoprotein particle receptor binding
Biological Process
GO:0001523 retinoid metabolic process
GO:0006898 receptor-mediated endocytosis
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007568 aging
GO:0007603 phototransduction, visible light
GO:0008203 cholesterol metabolic process
GO:0008283 cell proliferation
GO:0010875 positive regulation of cholesterol efflux
GO:0014912 negative regulation of smooth muscle cell migration
GO:0030178 negative regulation of Wnt signaling pathway
GO:0032370 positive regulation of lipid transport
GO:0032374 regulation of cholesterol transport
GO:0032429 regulation of phospholipase A2 activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0035909 aorta morphogenesis
GO:0042157 lipoprotein metabolic process
GO:0042953 lipoprotein transport
GO:0043277 apoptotic cell clearance
GO:0043524 negative regulation of neuron apoptotic process
GO:0051222 positive regulation of protein transport
GO:0097242 beta-amyloid clearance
GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005905 coated pit
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030136 clathrin-coated vesicle
GO:0030425 dendrite
GO:0030666 endocytic vesicle membrane
GO:0043025 neuronal cell body
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Wnt pathway
REACTOME
Scavenging of heme from plasma pathway
Retinoid metabolism and transport pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Visual phototransduction pathway
Disease pathway
KEGG
Alzheimer's disease pathway
Malaria pathway
INOH
PID BIOCARTA
PID NCI
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL Q6PJ72
UniProt Splice Variant
Entrez Gene 4035
UniGene Hs.162757 Hs.610685 Hs.618682
RefSeq NM_002332
HUGO HGNC:6692
OMIM 107770
CCDS CCDS8932
HPRD 00138
IMGT
EMBL AC023237 AC137628 AC137834 BC021204
GenPept AAH21204
RNA Seq Atlas 4035