InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LRP1

Summary

InnateDB Protein

IDBP-42180.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRP1

Protein Name

low density lipoprotein receptor-related protein 1

Synonyms

A2MR; APOER; APR; CD91; IGFBP3R; LRP; LRP1A; TGFBR5;

Species

Homo sapiens

Ensembl Protein

ENSP00000243077

InnateDB Gene

IDBG-42176 (LRP1)

Protein Structure

UniProt Annotation

Function

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.Functions as a receptor for Pseudomonas aeruginosa exotoxin A.

Subcellular Localization

Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit.Low-density lipoprotein receptor-related protein 1 515 kDa subunit: Cell membrane; Peripheral membrane protein; Extracellular side. Membrane, coated pit.Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.

Disease Associations

Tissue Specificity

Most abundant in liver, brain and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	76 [view]
Protein-Protein	76 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004872	receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0034185	apolipoprotein binding
GO:0042954	lipoprotein transporter activity
GO:0044822	poly(A) RNA binding
GO:0070325	lipoprotein particle receptor binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007568	aging
GO:0007603	phototransduction, visible light
GO:0008203	cholesterol metabolic process
GO:0008283	cell proliferation
GO:0010875	positive regulation of cholesterol efflux
GO:0014912	negative regulation of smooth muscle cell migration
GO:0030178	negative regulation of Wnt signaling pathway
GO:0032370	positive regulation of lipid transport
GO:0032374	regulation of cholesterol transport
GO:0032429	regulation of phospholipase A2 activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0035909	aorta morphogenesis
GO:0042157	lipoprotein metabolic process
GO:0042953	lipoprotein transport
GO:0043277	apoptotic cell clearance
GO:0043524	negative regulation of neuron apoptotic process
GO:0051222	positive regulation of protein transport
GO:0097242	beta-amyloid clearance
GO:2000587	negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005905	coated pit
GO:0016020	membrane
GO:0030136	clathrin-coated vesicle
GO:0030425	dendrite
GO:0030666	endocytic vesicle membrane
GO:0043025	neuronal cell body
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000033 LDLR class B repeat
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal

PFAM

PF00058
PF00008
PF07645
PF00057

PRINTS

PR00261

PIRSF

SMART

SM00135
SM00181
SM00179
SM00192

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt