InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CKAP5

Summary

InnateDB Gene

IDBG-42318.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CKAP5

Gene Name

cytoskeleton associated protein 5

Synonyms

ch-TOG; CHTOG; MSPS; TOG; TOGp

Species

Homo sapiens

Ensembl Gene

ENSG00000175216

Encoded Proteins

IDBP-42320

cytoskeleton associated protein 5

IDBP-42322

cytoskeleton associated protein 5

IDBP-583824

cytoskeleton associated protein 5

IDBP-587843

cytoskeleton associated protein 5

IDBP-601337

cytoskeleton associated protein 5

IDBP-598538

cytoskeleton associated protein 5

IDBP-603498

cytoskeleton associated protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:46743048-46846308

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000354558	ENSP00000346566
ENST00000312055	ENSP00000310227
ENST00000529230	ENSP00000432768
ENST00000533413
ENST00000525896	ENSP00000434523
ENST00000527333	ENSP00000431509
ENST00000526876	ENSP00000436052
ENST00000526943
ENST00000528593
ENST00000532321
ENST00000526496	ENSP00000436769
ENST00000525248

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004519	endonuclease activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0007051	spindle organization
GO:0007067	mitotic nuclear division
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity
GO:0050658	RNA transport
GO:0051297	centrosome organization

Cellular Component

GO:0000922	spindle pole
GO:0000930	gamma-tubulin complex
GO:0005813	centrosome
GO:0005829	cytosol
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0035371	microtubule plus-end
GO:0043234	protein complex