InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CKAP5

Summary

InnateDB Protein

IDBP-42322.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CKAP5

Protein Name

cytoskeleton associated protein 5

Synonyms

ch-TOG; CHTOG; MSPS; TOG; TOGp;

Species

Homo sapiens

Ensembl Protein

ENSP00000310227

InnateDB Gene

IDBG-42318 (CKAP5)

Protein Structure

UniProt Annotation

Function

Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. {ECO:0000269PubMed:12569123, ECO:0000269PubMed:21646404}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:21646404}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:21646404}. Note=Detected on centrosomes during interphase. Detected on spindle poles and microtubules during mitosis.

Disease Associations

Tissue Specificity

Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004519	endonuclease activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0007051	spindle organization
GO:0007067	mitotic nuclear division
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity
GO:0050658	RNA transport
GO:0051297	centrosome organization

Cellular Component

GO:0000922	spindle pole
GO:0000930	gamma-tubulin complex
GO:0005813	centrosome
GO:0005829	cytosol
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0035371	microtubule plus-end
GO:0043234	protein complex