Version 5.4
Homo sapiens Gene: PTPRG
Summary
InnateDB Gene IDBG-42524.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRG
Gene Name protein tyrosine phosphatase, receptor type, G
Synonyms HPTPG; PTPG; R-PTP-GAMMA; RPTPG
Species Homo sapiens
Ensembl Gene ENSG00000144724
Encoded Proteins
IDBP-42526
protein tyrosine phosphatase, receptor type, G
IDBP-481514
protein tyrosine phosphatase, receptor type, G
IDBP-813392
protein tyrosine phosphatase, receptor type, G
IDBP-813393
protein tyrosine phosphatase, receptor type, G
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:61561569-62297613
Strand Forward strand
Band p14.2
Transcripts
ENST00000295874 ENSP00000295874
ENST00000495879
ENST00000475527
ENST00000474889 ENSP00000418112
ENST00000475012
ENST00000485215
ENST00000468576
ENST00000618938 ENSP00000480407
ENST00000615556 ENSP00000484346
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 30 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0042802 identical protein binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007420 brain development
GO:0010977 negative regulation of neuron projection development
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021745
View Gene Order
ENSBTAG00000021911
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.594755 Hs.595541 Hs.605814
RefSeq NM_002841 XM_005265352
HUGO
OMIM
CCDS CCDS2895
HPRD 01478
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca