Version 5.4
Homo sapiens Gene: IL13
Summary
InnateDB Gene IDBG-42599.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL13
Gene Name interleukin 13
Synonyms IL-13; P600
Species Homo sapiens
Ensembl Gene ENSG00000169194
Encoded Proteins
IDBP-42603
interleukin 13
IDBP-808648
interleukin 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21097505
IL13 is a pro-M2/Th2 cytokine that induces alternative activation of macrophages. IL13 associates with IL13RA1 to activate the transcription factor STAT6.
PMID 22154382
IL13 dampens the innate immune response in airway epithelial cells via IRAK3-mediated inhibition of TLR2 signalling.
InnateDB Annotation from Orthologs
Summary
PMID 22154382
[Mus musculus] Il13 dampens the innate immune response in airway epithelial cells via Irak3-mediated inhibition of Tlr2 signalling. (Demonstrated in human)
PMID 24613091
[Mus musculus] IL13 produced by activated innate lymphoid cells type 2 (ILC2s) is critical for promoting the migration of activated lung dendritic cells to the draining lymph node, and in the differentiation of naive CD4+ T cells into Th2 cells
Entrez Gene
Summary This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:132656263-132661110
Strand Forward strand
Band q31.1
Transcripts
ENST00000304506 ENSP00000304915
ENST00000468334
ENST00000459878
ENST00000487267
ENST00000462480
ENST00000617259 ENSP00000479835
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 7 [view]
Protein-DNA 14 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 5 [view]
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005144 interleukin-13 receptor binding
GO:0005515 protein binding
Biological Process
GO:0001774 microglial cell activation
GO:0002639 positive regulation of immunoglobulin production
GO:0006928 cellular component movement
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0009612 response to mechanical stimulus
GO:0010155 regulation of proton transport
GO:0030890 positive regulation of B cell proliferation
GO:0032496 response to lipopolysaccharide
GO:0032723 positive regulation of connective tissue growth factor production
GO:0033861 negative regulation of NAD(P)H oxidase activity
GO:0035094 response to nicotine
GO:0042526 positive regulation of tyrosine phosphorylation of Stat6 protein
GO:0043032 positive regulation of macrophage activation
GO:0043270 positive regulation of ion transport
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0071260 cellular response to mechanical stimulus
GO:0071345 cellular response to cytokine stimulus
GO:0071635 negative regulation of transforming growth factor beta production
GO:1901215 negative regulation of neuron death
GO:1901247 negative regulation of lung ciliated cell differentiation
GO:1901251 positive regulation of lung goblet cell differentiation
GO:2000231 positive regulation of pancreatic stellate cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0009897 external side of plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000020383
View Gene Order
Pathways
NETPATH
NetPath_16
IL4 pathway
REACTOME
KEGG
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05310
Asthma pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-13 signaling pathway
INOH website
GPCR signaling pathway
PID NCI
il12_stat4pathway
IL12 signaling mediated by STAT4
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL Q4VB50 Q4VB53
UniProt Splice Variant
Entrez Gene 3596
UniGene
RefSeq NM_002188
HUGO HGNC:5973
OMIM 147683
CCDS CCDS4157
HPRD
IMGT
EMBL BC096138 BC096141
GenPept AAH96138 AAH96141
RNA Seq Atlas 3596

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca