InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL13

Summary

InnateDB Protein

IDBP-42603.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL13

Protein Name

interleukin 13

Synonyms

IL-13; P600;

Species

Homo sapiens

Ensembl Protein

ENSP00000304915

InnateDB Gene

IDBG-42599 (IL13)

Protein Structure

UniProt Annotation

Function

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

Subcellular Localization

Secreted.

Disease Associations

Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	7 [view]
Protein-DNA	14 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	5 [view]
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005144	interleukin-13 receptor binding
GO:0005515	protein binding

Biological Process

GO:0001774	microglial cell activation
GO:0002639	positive regulation of immunoglobulin production
GO:0006928	cellular component movement
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0009612	response to mechanical stimulus
GO:0010155	regulation of proton transport
GO:0030890	positive regulation of B cell proliferation
GO:0032496	response to lipopolysaccharide
GO:0032723	positive regulation of connective tissue growth factor production
GO:0033861	negative regulation of NAD(P)H oxidase activity
GO:0035094	response to nicotine
GO:0042526	positive regulation of tyrosine phosphorylation of Stat6 protein
GO:0043032	positive regulation of macrophage activation
GO:0043270	positive regulation of ion transport
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050714	positive regulation of protein secretion
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0071260	cellular response to mechanical stimulus
GO:0071345	cellular response to cytokine stimulus
GO:0071635	negative regulation of transforming growth factor beta production
GO:1901215	negative regulation of neuron death
GO:1901247	negative regulation of lung ciliated cell differentiation
GO:1901251	positive regulation of lung goblet cell differentiation
GO:2000231	positive regulation of pancreatic stellate cell proliferation