InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRIA2

Summary

InnateDB Gene

IDBG-42633.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIA2

Gene Name

glutamate receptor, ionotropic, AMPA 2

Synonyms

GluA2; GluR-K2; GLUR2; GLURB; HBGR2

Species

Homo sapiens

Ensembl Gene

ENSG00000120251

Encoded Proteins

IDBP-42635

glutamate receptor, ionotropic, AMPA 2

IDBP-42637

glutamate receptor, ionotropic, AMPA 2

IDBP-42639

glutamate receptor, ionotropic, AMPA 2

IDBP-242860

glutamate receptor, ionotropic, AMPA 2

IDBP-476462

glutamate receptor, ionotropic, AMPA 2

IDBP-480800

glutamate receptor, ionotropic, AMPA 2

IDBP-475157

glutamate receptor, ionotropic, AMPA 2

IDBP-478989

glutamate receptor, ionotropic, AMPA 2

IDBP-479574

glutamate receptor, ionotropic, AMPA 2

IDBP-478389

glutamate receptor, ionotropic, AMPA 2

IDBP-475944

glutamate receptor, ionotropic, AMPA 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:157204182-157366075

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000296526	ENSP00000296526
ENST00000264426	ENSP00000264426
ENST00000323661	ENSP00000318144
ENST00000393815	ENSP00000377403
ENST00000504801
ENST00000512774	ENSP00000423988
ENST00000507898	ENSP00000426845
ENST00000509417	ENSP00000425217
ENST00000471736
ENST00000506284	ENSP00000426513
ENST00000505888	ENSP00000422038
ENST00000503437	ENSP00000426784
ENST00000510854	ENSP00000423229
ENST00000503980

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004971	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0030666	endocytic vesicle membrane
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0045202	synapse
GO:0045211	postsynaptic membrane