Version 5.4
Homo sapiens Gene: PACSIN3
Summary
InnateDB Gene IDBG-42731.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PACSIN3
Gene Name protein kinase C and casein kinase substrate in neurons 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165912
Encoded Proteins
IDBP-42733
protein kinase C and casein kinase substrate in neurons 3
IDBP-604006
protein kinase C and casein kinase substrate in neurons 3
IDBP-589662
protein kinase C and casein kinase substrate in neurons 3
IDBP-584381
protein kinase C and casein kinase substrate in neurons 3
IDBP-584195
protein kinase C and casein kinase substrate in neurons 3
IDBP-598847
protein kinase C and casein kinase substrate in neurons 3
IDBP-602528
protein kinase C and casein kinase substrate in neurons 3
IDBP-590845
protein kinase C and casein kinase substrate in neurons 3
IDBP-595935
protein kinase C and casein kinase substrate in neurons 3
IDBP-583370
protein kinase C and casein kinase substrate in neurons 3
IDBP-589655
protein kinase C and casein kinase substrate in neurons 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:47177525-47186443
Strand Reverse strand
Band p11.2
Transcripts
ENST00000298838 ENSP00000298838
ENST00000532457 ENSP00000431948
ENST00000533686 ENSP00000433962
ENST00000528462 ENSP00000437252
ENST00000530513 ENSP00000431924
ENST00000528201 ENSP00000434521
ENST00000531226 ENSP00000434699
ENST00000525725 ENSP00000435638
ENST00000530405 ENSP00000435672
ENST00000524509 ENSP00000431861
ENST00000539589 ENSP00000440945
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008289 lipid binding
GO:0019855 calcium channel inhibitor activity
Biological Process
GO:0006897 endocytosis
GO:0045806 negative regulation of endocytosis
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051926 negative regulation of calcium ion transport
GO:0097320 membrane tubulation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027257
View Gene Order
ENSBTAG00000009576
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.334639 Hs.736374
RefSeq NM_001184974 NM_001184975 NM_016223
HUGO
OMIM
CCDS CCDS31481
HPRD 05937
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca