InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PACSIN3

Summary

InnateDB Protein

IDBP-584381.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PACSIN3

Protein Name

protein kinase C and casein kinase substrate in neurons 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000437252

InnateDB Gene

IDBG-42731 (PACSIN3)

Protein Structure

UniProt Annotation

Function

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11179684}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Detected at the inner aspect of the plasma membrane in myotubes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney. {ECO:0000269PubMed:11082044, ECO:0000269PubMed:11179684}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0008289	lipid binding
GO:0019855	calcium channel inhibitor activity

Biological Process

GO:0006897	endocytosis
GO:0045806	negative regulation of endocytosis
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0051926	negative regulation of calcium ion transport
GO:0097320	membrane tubulation