Homo sapiens Gene: ACP2
Summary
InnateDB Gene IDBG-42850.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACP2
Gene Name acid phosphatase 2, lysosomal
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134575
Encoded Proteins
acid phosphatase 2, lysosomal
acid phosphatase 2, lysosomal
acid phosphatase 2, lysosomal
acid phosphatase 2, lysosomal
acid phosphatase 2, lysosomal
acid phosphatase 2, lysosomal
acid phosphatase 2, lysosomal
acid phosphatase 2, lysosomal
acid phosphatase 2, lysosomal
acid phosphatase 2, lysosomal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Mutations in this gene or in the related alpha subunit gene cause acid phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:47239302-47248906
Strand Reverse strand
Band p11.2
Transcripts
ENST00000256997 ENSP00000256997
ENST00000444355 ENSP00000414911
ENST00000534752
ENST00000529444 ENSP00000436658
ENST00000534448
ENST00000527256 ENSP00000432205
ENST00000531004 ENSP00000435261
ENST00000533929 ENSP00000432439
ENST00000525230
ENST00000531547 ENSP00000432466
ENST00000529663 ENSP00000436487
ENST00000524769
ENST00000530453 ENSP00000434205
ENST00000529788 ENSP00000436828
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003993 acid phosphatase activity
Biological Process
GO:0001501 skeletal system development
GO:0007040 lysosome organization
GO:0016311 dephosphorylation
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043202 lysosomal lumen
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Riboflavin metabolism pathway
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E9PQW9
UniProt Splice Variant
Entrez Gene 53
UniGene
RefSeq NM_001131064 NM_001610
HUGO HGNC:123
OMIM 171650
CCDS CCDS44583 CCDS7928
HPRD 01375
IMGT
EMBL AC018410
GenPept
RNA Seq Atlas 53