InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACP2

Summary

InnateDB Protein

IDBP-42852.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACP2

Protein Name

acid phosphatase 2, lysosomal

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000256997

InnateDB Gene

IDBG-42850 (ACP2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Lysosome membrane; Single-pass membrane protein; Lumenal side. Lysosome lumen. Note=The soluble form arises by proteolytic processing of the membrane-bound form.

Disease Associations

Acid phosphatase deficiency (ACPHD) [MIM:200950]: A disorder characterized by intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding and death in early infancy. Lysosomal acid phosphatase is deficient in cultured fibroblasts and multiple tissues. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003993	acid phosphatase activity

Biological Process

GO:0001501	skeletal system development
GO:0007040	lysosome organization
GO:0016311	dephosphorylation

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome