Homo sapiens Gene: TFF2
Summary
InnateDB Gene IDBG-4324.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFF2
Gene Name trefoil factor 2
Synonyms SML1; SP;
Species Homo sapiens
Ensembl Gene ENSG00000160181
Encoded Proteins
trefoil factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:42346357-42351128
Strand Reverse strand
Band q22.3
Transcripts
ENST00000291526 ENSP00000291526
ENST00000463771
ENST00000475297
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031723 CXCR4 chemokine receptor binding
Biological Process
GO:0007586 digestion
GO:0008284 positive regulation of cell proliferation
GO:0019722 calcium-mediated signaling
GO:0030334 regulation of cell migration
GO:0043031 negative regulation of macrophage activation
GO:0050728 negative regulation of inflammatory response
GO:0060455 negative regulation of gastric acid secretion
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Trefoil factors initiate mucosal healing [Biocarta view]
PID NCI
Cross-References
SwissProt Q03403
TrEMBL
UniProt Splice Variant
Entrez Gene 7032
UniGene
RefSeq NM_005423
HUGO HGNC:11756
OMIM 182590
CCDS CCDS13684
HPRD 01682
IMGT
EMBL AB038162 BC032820 U47289 U47290 U47291 U47292 X51698
GenPept AAB05397 AAH32820 BAB13730 CAA35995
RNA Seq Atlas 7032