InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TFF2

Summary

InnateDB Protein

IDBP-4326.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFF2

Protein Name

trefoil factor 2

Synonyms

SML1; SP;

Species

Homo sapiens

Ensembl Protein

ENSP00000291526

InnateDB Gene

IDBG-4324 (TFF2)

Protein Structure

UniProt Annotation

Function

Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Stomach.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031723	CXCR4 chemokine receptor binding

Biological Process

GO:0007586	digestion
GO:0008284	positive regulation of cell proliferation
GO:0019722	calcium-mediated signaling
GO:0030334	regulation of cell migration
GO:0043031	negative regulation of macrophage activation
GO:0050728	negative regulation of inflammatory response
GO:0060455	negative regulation of gastric acid secretion
GO:0070098	chemokine-mediated signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade