Homo sapiens Gene: SPI1
Summary
InnateDB Gene IDBG-43260.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPI1
Gene Name spleen focus forming virus (SFFV) proviral integration oncogene spi1
Synonyms OF; PU.1; SFPI1; SPI-1; SPI-A;
Species Homo sapiens
Ensembl Gene ENSG00000066336
Encoded Proteins
spleen focus forming virus (SFFV) proviral integration oncogene spi1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
spleen focus forming virus (SFFV) proviral integration oncogene spi1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
SPI1 (PU.1) directly regulates FLT3 kinase in a concentration-dependent manner, and is a critical regulator of both conventional and plasmacytoid dendritic cell development.
Entrez Gene
Summary This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:47354860-47378576
Strand Reverse strand
Band p11.2
Transcripts
ENST00000378538 ENSP00000367799
ENST00000227163 ENSP00000227163
ENST00000533030 ENSP00000443865
ENST00000533968 ENSP00000438846
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 101 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Experimentally validated
Total 105 [view]
Protein-Protein 68 [view]
Protein-DNA 37 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 61 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001047 core promoter binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085 RNA polymerase II transcription factor binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0051525 NFAT protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001944 vasculature development
GO:0002320 lymphoid progenitor cell differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0030098 lymphocyte differentiation
GO:0030218 erythrocyte differentiation
GO:0030225 macrophage differentiation
GO:0030851 granulocyte differentiation
GO:0035019 somatic stem cell maintenance
GO:0043011 myeloid dendritic cell differentiation
GO:0043966 histone H3 acetylation
GO:0044027 hypermethylation of CpG island
GO:0045087 innate immune response (InnateDB)
GO:0045347 negative regulation of MHC class II biosynthetic process
GO:0045646 regulation of erythrocyte differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060033 anatomical structure regression
GO:0090241 negative regulation of histone H4 acetylation
GO:1902262 apoptotic process involved in patterning of blood vessels
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL4 pathway
RANKL pathway
REACTOME
KEGG
Osteoclast differentiation pathway
Pathways in cancer pathway
Acute myeloid leukemia pathway
INOH
PID BIOCARTA
PID NCI
Regulation of retinoblastoma protein
Validated targets of C-MYC transcriptional repression
Glucocorticoid receptor regulatory network
C-MYB transcription factor network
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL F5GZ94
UniProt Splice Variant
Entrez Gene 6688
UniGene Hs.502511
RefSeq NM_003120 NM_001080547
HUGO HGNC:11241
OMIM 165170
CCDS CCDS7933 CCDS44591
HPRD 01305
IMGT
EMBL AC090559 AC090582
GenPept
RNA Seq Atlas 6688