InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SPI1

Summary

InnateDB Gene

IDBG-43260.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPI1

Gene Name

spleen focus forming virus (SFFV) proviral integration oncogene spi1

Synonyms

OF; PU.1; SFPI1; SPI-1; SPI-A

Species

Homo sapiens

Ensembl Gene

ENSG00000066336

Encoded Proteins

IDBP-43262

spleen focus forming virus (SFFV) proviral integration oncogene spi1

IDBP-43264

spleen focus forming virus (SFFV) proviral integration oncogene spi1

IDBP-597345

spleen focus forming virus (SFFV) proviral integration oncogene spi1

IDBP-583203

spleen focus forming virus (SFFV) proviral integration oncogene spi1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20510871

SPI1 (PU.1) directly regulates FLT3 kinase in a concentration-dependent manner, and is a critical regulator of both conventional and plasmacytoid dendritic cell development.

Entrez Gene

Summary

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:47354860-47378576

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000378538	ENSP00000367799
ENST00000227163	ENSP00000227163
ENST00000533030	ENSP00000443865
ENST00000533968	ENSP00000438846

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 101 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Experimentally validated
Total	105 [view]
Protein-Protein	68 [view]
Protein-DNA	37 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001047	core promoter binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0051525	NFAT protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001944	vasculature development
GO:0002320	lymphoid progenitor cell differentiation
GO:0002573	myeloid leukocyte differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030098	lymphocyte differentiation
GO:0030218	erythrocyte differentiation
GO:0030225	macrophage differentiation
GO:0030851	granulocyte differentiation
GO:0035019	somatic stem cell maintenance
GO:0043011	myeloid dendritic cell differentiation
GO:0043966	histone H3 acetylation
GO:0044027	hypermethylation of CpG island
GO:0045087	innate immune response (InnateDB)
GO:0045347	negative regulation of MHC class II biosynthetic process
GO:0045646	regulation of erythrocyte differentiation
GO:0045814	negative regulation of gene expression, epigenetic
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060033	anatomical structure regression
GO:0090241	negative regulation of histone H4 acetylation
GO:1902262	apoptotic process involved in patterning of blood vessels

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000002111

View Gene Order

ENSBTAG00000021709

Not yet available

Pathways

NETPATH

NetPath_16

IL4 pathway

NetPath_21

RANKL pathway

REACTOME

KEGG

hsa05221

Acute myeloid leukemia pathway

hsa05200

Pathways in cancer pathway

hsa04380

Osteoclast differentiation pathway

INOH

PID NCI

rb_1pathway

Regulation of retinoblastoma protein

myc_represspathway

Validated targets of C-MYC transcriptional repression

reg_gr_pathway

Glucocorticoid receptor regulatory network

cmyb_pathway

C-MYB transcription factor network

il4_2pathway

IL4-mediated signaling events

Cross-References

SwissProt

P17947

TrEMBL

UniProt Splice Variant

Entrez Gene

6688

UniGene

Hs.502511

RefSeq

NM_001080547 NM_003120

HUGO

HGNC:11241

OMIM

165170

CCDS

CCDS44591 CCDS7933

HPRD

01305

IMGT

EMBL

AC090559 AC090582 AL532058 X52056

GenPept

CAA36281

RNA Seq Atlas

6688