InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPI1

Summary

InnateDB Protein

IDBP-43264.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPI1

Protein Name

spleen focus forming virus (SFFV) proviral integration oncogene spi1

Synonyms

OF; PU.1; SFPI1; SPI-1; SPI-A;

Species

Homo sapiens

Ensembl Protein

ENSP00000227163

InnateDB Gene

IDBG-43260 (SPI1)

Protein Structure

UniProt Annotation

Function

Binds to the PU-box, a purine-rich DNA sequence (5'- GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00237, ECO:0000269PubMed:23166356}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 101 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Experimentally validated
Total	105 [view]
Protein-Protein	68 [view]
Protein-DNA	37 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001047	core promoter binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0051525	NFAT protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001944	vasculature development
GO:0002320	lymphoid progenitor cell differentiation
GO:0002573	myeloid leukocyte differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0030098	lymphocyte differentiation
GO:0030218	erythrocyte differentiation
GO:0030225	macrophage differentiation
GO:0030851	granulocyte differentiation
GO:0035019	somatic stem cell maintenance
GO:0043011	myeloid dendritic cell differentiation
GO:0043966	histone H3 acetylation
GO:0044027	hypermethylation of CpG island
GO:0045087	innate immune response (InnateDB)
GO:0045347	negative regulation of MHC class II biosynthetic process
GO:0045646	regulation of erythrocyte differentiation
GO:0045814	negative regulation of gene expression, epigenetic
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060033	anatomical structure regression
GO:0090241	negative regulation of histone H4 acetylation
GO:1902262	apoptotic process involved in patterning of blood vessels