Homo sapiens Gene: MAGI1
Summary
InnateDB Gene IDBG-43316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAGI1
Gene Name membrane associated guanylate kinase, WW and PDZ domain containing 1
Synonyms AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1; Magi1d; TNRC19; WWP3;
Species Homo sapiens
Ensembl Gene ENSG00000151276
Encoded Proteins
membrane associated guanylate kinase, WW and PDZ domain containing 1
membrane associated guanylate kinase, WW and PDZ domain containing 1
membrane associated guanylate kinase, WW and PDZ domain containing 1
membrane associated guanylate kinase, WW and PDZ domain containing 1
membrane associated guanylate kinase, WW and PDZ domain containing 1
membrane associated guanylate kinase, WW and PDZ domain containing 1
membrane associated guanylate kinase, WW and PDZ domain containing 1
membrane associated guanylate kinase, WW and PDZ domain containing 1
membrane associated guanylate kinase, WW and PDZ domain containing 1
membrane associated guanylate kinase, WW and PDZ domain containing 1
membrane associated guanylate kinase, WW and PDZ domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:65353525-66038834
Strand Reverse strand
Band p14.1
Transcripts
ENST00000330909 ENSP00000331157
ENST00000402939 ENSP00000385450
ENST00000463103 ENSP00000418177
ENST00000483466 ENSP00000420323
ENST00000460329 ENSP00000418862
ENST00000497477 ENSP00000424369
ENST00000472257 ENSP00000420796
ENST00000480729
ENST00000468159
ENST00000470990
ENST00000494271
ENST00000479287 ENSP00000418044
ENST00000464060
ENST00000476703
ENST00000476403
ENST00000496734
ENST00000611645 ENSP00000480920
ENST00000613799 ENSP00000478457
ENST00000621418 ENSP00000477591
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 39 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0051393 alpha-actinin binding
Biological Process
GO:0006461 protein complex assembly
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0070997 neuron death
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005923 tight junction
GO:0030054 cell junction
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
Tight junction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96QZ7
TrEMBL
UniProt Splice Variant
Entrez Gene 9223
UniGene Hs.476636
RefSeq NM_015520 NM_001033057 NM_004742 XM_006713413 XM_005265564 XM_005265563 XM_006713409 XM_006713408 XM_006713407 XM_006713412 XM_006713411
HUGO HGNC:946
OMIM 602625
CCDS CCDS33781 CCDS33780 CCDS2904
HPRD 04020
IMGT
EMBL AB010894 AC104438 AC112516 AC121493 AC145425 AF401654 AF401655 AF401656 AK289803 U80754 U96115
GenPept AAC04844 AAC51326 AAK94064 AAK94065 AAK94066 BAA32002 BAF82492
RNA Seq Atlas 9223