Version 5.4
Homo sapiens Gene: MAGI1
Summary
InnateDB Gene IDBG-43316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAGI1
Gene Name membrane associated guanylate kinase, WW and PDZ domain containing 1
Synonyms AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1; Magi1d; TNRC19; WWP3
Species Homo sapiens
Ensembl Gene ENSG00000151276
Encoded Proteins
IDBP-43324
membrane associated guanylate kinase, WW and PDZ domain containing 1
IDBP-295509
membrane associated guanylate kinase, WW and PDZ domain containing 1
IDBP-480715
membrane associated guanylate kinase, WW and PDZ domain containing 1
IDBP-476076
membrane associated guanylate kinase, WW and PDZ domain containing 1
IDBP-485212
membrane associated guanylate kinase, WW and PDZ domain containing 1
IDBP-483816
membrane associated guanylate kinase, WW and PDZ domain containing 1
IDBP-475811
membrane associated guanylate kinase, WW and PDZ domain containing 1
IDBP-474983
membrane associated guanylate kinase, WW and PDZ domain containing 1
IDBP-809455
membrane associated guanylate kinase, WW and PDZ domain containing 1
IDBP-809458
membrane associated guanylate kinase, WW and PDZ domain containing 1
IDBP-809459
membrane associated guanylate kinase, WW and PDZ domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:65353525-66038834
Strand Reverse strand
Band p14.1
Transcripts
ENST00000330909 ENSP00000331157
ENST00000402939 ENSP00000385450
ENST00000463103 ENSP00000418177
ENST00000483466 ENSP00000420323
ENST00000460329 ENSP00000418862
ENST00000497477 ENSP00000424369
ENST00000472257 ENSP00000420796
ENST00000480729
ENST00000468159
ENST00000470990
ENST00000494271
ENST00000479287 ENSP00000418044
ENST00000464060
ENST00000476703
ENST00000476403
ENST00000496734
ENST00000611645 ENSP00000480920
ENST00000613799 ENSP00000478457
ENST00000621418 ENSP00000477591
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 39 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0051393 alpha-actinin binding
Biological Process
GO:0006461 protein complex assembly
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0070997 neuron death
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005923 tight junction
GO:0030054 cell junction
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045095
View Gene Order
ENSBTAG00000010581
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.476636
RefSeq NM_001033057 NM_004742 NM_015520 XM_005265563 XM_005265564 XM_006713407 XM_006713408 XM_006713409 XM_006713411 XM_006713412 XM_006713413
HUGO
OMIM
CCDS CCDS2904 CCDS33780 CCDS33781
HPRD 04020
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca