InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAGI1

Summary

InnateDB Protein

IDBP-295509.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAGI1

Protein Name

membrane associated guanylate kinase, WW and PDZ domain containing 1

Synonyms

AIP-3; AIP3; BAIAP1; BAP-1; BAP1; MAGI-1; Magi1d; TNRC19; WWP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000385450

InnateDB Gene

IDBG-43316 (MAGI1)

Protein Structure

UniProt Annotation

Function

May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, tight junction {ECO:0000269PubMed:11969287}. Cell membrane {ECO:0000269PubMed:11969287}; Peripheral membrane protein {ECO:0000269PubMed:11969287}. Note=Localizes to epithelial cells tight junctions.

Disease Associations

Tissue Specificity

Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain. {ECO:0000269PubMed:11969287, ECO:0000269PubMed:9647693, ECO:0000269PubMed:9647739}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	39 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0051393	alpha-actinin binding

Biological Process

GO:0006461	protein complex assembly
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0070997	neuron death

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0030054	cell junction
GO:0042995	cell projection

Protein Structure and Domains

PDB ID

InterPro

IPR001202 WW domain
IPR001478 PDZ domain
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00397
PF00595
PF13180
PF00625

PRINTS

PIRSF

SMART

SM00456
SM00228
SM00072

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96QZ7