Homo sapiens Gene: SCN1B
Summary
InnateDB Gene IDBG-43352.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCN1B
Gene Name sodium channel, voltage-gated, type I, beta subunit
Synonyms ATFB13; BRGDA5; GEFSP1;
Species Homo sapiens
Ensembl Gene ENSG00000105711
Encoded Proteins
sodium channel, voltage-gated, type I, beta
sodium channel, voltage-gated, type I, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:35030684-35040448
Strand Forward strand
Band q13.11
Transcripts
ENST00000262631 ENSP00000262631
ENST00000415950 ENSP00000396915
ENST00000602150
ENST00000596348
ENST00000595652 ENSP00000468848
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005248 voltage-gated sodium channel activity
GO:0005515 protein binding
GO:0017080 sodium channel regulator activity
GO:0019871 sodium channel inhibitor activity
GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential
Biological Process
GO:0002028 regulation of sodium ion transport
GO:0006814 sodium ion transport
GO:0007155 cell adhesion
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0010765 positive regulation of sodium ion transport
GO:0010976 positive regulation of neuron projection development
GO:0019227 neuronal action potential propagation
GO:0021966 corticospinal neuron axon guidance
GO:0035725 sodium ion transmembrane transport
GO:0040011 locomotion
GO:0046684 response to pyrethroid
GO:0051899 membrane depolarization
GO:0060048 cardiac muscle contraction
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
GO:0061337 cardiac conduction
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086047 membrane depolarization during Purkinje myocyte cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:2000649 regulation of sodium ion transmembrane transporter activity
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005576 extracellular region
GO:0014704 intercalated disc
GO:0030315 T-tubule
GO:0033268 node of Ranvier
GO:0034706 sodium channel complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Interaction between L1 and Ankyrins pathway
Axon guidance pathway
L1CAM interactions pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL B4DI92
UniProt Splice Variant
Entrez Gene 6324
UniGene
RefSeq NM_001037 NM_199037 XM_005259144
HUGO HGNC:10586
OMIM 600235
CCDS CCDS12441 CCDS46047
HPRD 02581
IMGT
EMBL AC020907 AK295477
GenPept BAG58404
RNA Seq Atlas 6324