Version 5.4
Homo sapiens Gene: KLHL2
Summary
InnateDB Gene IDBG-43532.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLHL2
Gene Name kelch-like 2, Mayven (Drosophila)
Synonyms ABP-KELCH; MAV; MAYVEN
Species Homo sapiens
Ensembl Gene ENSG00000109466
Encoded Proteins
IDBP-43534
kelch-like 2, Mayven (Drosophila)
IDBP-379487
kelch-like 2, Mayven (Drosophila)
IDBP-479847
kelch-like 2, Mayven (Drosophila)
IDBP-480550
kelch-like 2, Mayven (Drosophila)
IDBP-480768
kelch-like 2, Mayven (Drosophila)
IDBP-477885
kelch-like 2, Mayven (Drosophila)
IDBP-473993
kelch-like 2, Mayven (Drosophila)
IDBP-601482
kelch-like 2, Mayven (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 4:165207618-165323156
Strand Forward strand
Band q32.3
Transcripts
ENST00000226725 ENSP00000226725
ENST00000421009 ENSP00000408974
ENST00000511305 ENSP00000422113
ENST00000509704 ENSP00000421324
ENST00000514860 ENSP00000424198
ENST00000506824 ENSP00000421844
ENST00000506541
ENST00000506761 ENSP00000424108
ENST00000509028
ENST00000538127 ENSP00000437526
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031605
View Gene Order
ENSBTAG00000005263
Not yet available
Cross-References
SwissProt
TrEMBL D6R9G5
UniProt Splice Variant
Entrez Gene 11275
UniGene Hs.388668
RefSeq NM_001161521 NM_001161522 NM_007246 XM_005262710 XM_006714074
HUGO HGNC:6353
OMIM 605774
CCDS CCDS34094 CCDS54815 CCDS54816
HPRD 09311
IMGT
EMBL AC012504 AC055120 AC107059
GenPept
RNA Seq Atlas 11275

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca