Version 5.4
Homo sapiens Protein: KLHL2
Summary
InnateDB Protein IDBP-601482.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLHL2
Protein Name kelch-like 2, Mayven (Drosophila)
Synonyms ABP-KELCH; MAV; MAYVEN;
Species Homo sapiens
Ensembl Protein ENSP00000437526
InnateDB Gene IDBG-43532 (KLHL2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
GO:0031463 Cul3-RING ubiquitin ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
PFAM PF01344
PF07646
PF07707
PF00651
PRINTS
PIRSF
SMART SM00612
SM00875
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95198
PhosphoSite PhosphoSite-O95198
TrEMBL B4DFZ5
UniProt Splice Variant
Entrez Gene 11275
UniGene Hs.388668
RefSeq NP_001154994
HUGO HGNC:6353
OMIM 605774
CCDS CCDS54816
HPRD 09311
IMGT
EMBL AC012504 AC055120 AC107059 AF059569 AK294103 AK294336 AK315372 BC022503 BC036468
GenPept AAC67502 AAH22503 AAH36468 BAG37765 BAG57438 BAG57606

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca