Homo sapiens Gene: SMTN
Summary
InnateDB Gene IDBG-4376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMTN
Gene Name smoothelin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183963
Encoded Proteins
smoothelin
smoothelin
smoothelin
smoothelin
smoothelin
smoothelin
smoothelin
smoothelin
smoothelin
smoothelin
smoothelin
smoothelin
smoothelin
smoothelin
smoothelin
smoothelin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:31064105-31104757
Strand Forward strand
Band q12.2
Transcripts
ENST00000333137 ENSP00000329532
ENST00000358743 ENSP00000351593
ENST00000347557 ENSP00000328635
ENST00000404574 ENSP00000383919
ENST00000432777 ENSP00000398663
ENST00000422839 ENSP00000390453
ENST00000440425 ENSP00000401341
ENST00000426927 ENSP00000399432
ENST00000438223 ENSP00000409925
ENST00000416786 ENSP00000409990
ENST00000431481 ENSP00000394637
ENST00000455608 ENSP00000392329
ENST00000482444 ENSP00000485277
ENST00000475548
ENST00000497697
ENST00000489337
ENST00000460658
ENST00000466272
ENST00000493335
ENST00000472911
ENST00000624247 ENSP00000485089
ENST00000612341 ENSP00000479578
ENST00000619644 ENSP00000484398
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
Biological Process
GO:0006939 smooth muscle contraction
GO:0007517 muscle organ development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL C9JGQ0
UniProt Splice Variant
Entrez Gene 6525
UniGene Hs.738578
RefSeq NM_001207018 NM_134269 NM_134270 NM_006932 NM_001207017 XM_006724306 XM_006724303 XM_006724298
HUGO HGNC:11126
OMIM 602127
CCDS CCDS13888 CCDS13887 CCDS13886 CCDS74846 CCDS74845
HPRD 03675
IMGT
EMBL AC005005
GenPept
RNA Seq Atlas 6525