Version 5.4
Homo sapiens Protein: SMTN
Summary
InnateDB Protein IDBP-4378.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMTN
Protein Name smoothelin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000329532
InnateDB Gene IDBG-4376 (SMTN)
Protein Structure
UniProt Annotation
Function Structural protein of the cytoskeleton.
Subcellular Localization Cytoplasm, cytoskeleton. Note=Exhibits a filamentous organization.
Disease Associations
Tissue Specificity Smooth muscle; contractile or vascular (for the long form).
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
Biological Process
GO:0006939 smooth muscle contraction
GO:0007517 muscle organ development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001715 Calponin homology domain
IPR022189 Smoothelin cytoskeleton protein
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
PFAM PF00307
PF12510
PF11971
PRINTS
PIRSF
SMART SM00033
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P53814
PhosphoSite PhosphoSite-P53814
TrEMBL C9JP19
UniProt Splice Variant
Entrez Gene 6525
UniGene Hs.738578
RefSeq NP_599031
HUGO HGNC:11126
OMIM 602127
CCDS CCDS13888
HPRD 03675
IMGT
EMBL AC005005 AF064238 AF115552 AF115553 AF115554 AF115555 AF115556 AF115557 AF115558 AF115559 AF115560 AF115561 AF115562 AF115563 AF115564 AF115565 AF115566 AF115567 AF115568 AF115569 AF115570 AJ010306 AK095930 AY061971 AY061972 BC034237 CH471095 Y13492 Z49989
GenPept AAD15619 AAF01481 AAF03562 AAF03563 AAH34237 AAL36149 AAL36150 BAG53168 CAA09077 CAA73884 CAA90281 EAW59930

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca