Version 5.4
Homo sapiens Gene: USF2
Summary
InnateDB Gene IDBG-43810.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USF2
Gene Name upstream transcription factor 2, c-fos interacting
Synonyms bHLHb12; FIP
Species Homo sapiens
Ensembl Gene ENSG00000105698
Encoded Proteins
IDBP-43812
upstream transcription factor 2, c-fos interacting
IDBP-43814
upstream transcription factor 2, c-fos interacting
IDBP-43816
upstream transcription factor 2, c-fos interacting
IDBP-813247
upstream transcription factor 2, c-fos interacting
IDBP-760213
IDBP-761461
IDBP-762639
IDBP-765139
IDBP-761342
IDBP-760744
IDBP-761323
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:35268978-35279821
Strand Forward strand
Band q13.12
Transcripts
ENST00000343550 ENSP00000340633
ENST00000379134 ENSP00000368429
ENST00000222305 ENSP00000222305
ENST00000602164 ENSP00000477020
ENST00000595068 ENSP00000471099
ENST00000600341
ENST00000594264
ENST00000599625 ENSP00000470081
ENST00000593708
ENST00000600898
ENST00000599471 ENSP00000469364
ENST00000594064 ENSP00000471511
ENST00000598058 ENSP00000469585
ENST00000596380 ENSP00000471775
ENST00000597671 ENSP00000470277
ENST00000607959
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 22 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007595 lactation
GO:0019086 late viral transcription
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0055088 lipid homeostasis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000058239
View Gene Order
ENSBTAG00000017035
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
fra_pathway
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.454534
RefSeq NM_003367 NM_207291 XM_005259197
HUGO
OMIM
CCDS CCDS12452 CCDS12453
HPRD 02668
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca