Version 5.4
Homo sapiens Gene: METTL1
Summary
InnateDB Gene IDBG-43845.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol METTL1
Gene Name methyltransferase like 1
Synonyms C12orf1; TRM8; TRMT8; YDL201w
Species Homo sapiens
Ensembl Gene ENSG00000037897
Encoded Proteins
IDBP-43847
methyltransferase like 1
IDBP-43849
methyltransferase like 1
IDBP-597302
methyltransferase like 1
IDBP-599613
methyltransferase like 1
IDBP-595265
methyltransferase like 1
IDBP-598322
methyltransferase like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:57768471-57772793
Strand Reverse strand
Band q14.1
Transcripts
ENST00000324871 ENSP00000314441
ENST00000257848 ENSP00000257848
ENST00000547653 ENSP00000447838
ENST00000548504 ENSP00000449397
ENST00000551117 ENSP00000447988
ENST00000553125 ENSP00000448342
ENST00000548681
ENST00000549773
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 35 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0005515 protein binding
GO:0008176 tRNA (guanine-N7-)-methyltransferase activity
Biological Process
GO:0006400 tRNA modification
GO:0030488 tRNA methylation
GO:0036265 RNA (guanine-N7)-methylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006732
View Gene Order
ENSBTAG00000016908
Not yet available
Cross-References
SwissProt Q9UBP6
TrEMBL A0A024RB62 F8VSD9
UniProt Splice Variant
Entrez Gene 4234
UniGene
RefSeq NM_005371 NM_023033
HUGO HGNC:7030
OMIM 604466
CCDS CCDS8955 CCDS8956
HPRD
IMGT
EMBL AC025165 AK223202 AK314851 BC000550 CH471054 X96698 Y18642 Y18643
GenPept AAH00550 BAD96922 BAG37368 CAA65470 CAA77238 CAA77239 EAW97066 EAW97071
RNA Seq Atlas 4234

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca