Version 5.4
Homo sapiens Gene: MSL3
Summary
InnateDB Gene IDBG-43905.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSL3
Gene Name male-specific lethal 3 homolog (Drosophila)
Synonyms MSL3L1
Species Homo sapiens
Ensembl Gene ENSG00000005302
Encoded Proteins
IDBP-43907
male-specific lethal 3 homolog (Drosophila)
IDBP-43909
male-specific lethal 3 homolog (Drosophila)
IDBP-43911
male-specific lethal 3 homolog (Drosophila)
IDBP-43913
male-specific lethal 3 homolog (Drosophila)
IDBP-43915
male-specific lethal 3 homolog (Drosophila)
IDBP-43917
male-specific lethal 3 homolog (Drosophila)
IDBP-232878
male-specific lethal 3 homolog (Drosophila)
IDBP-361985
male-specific lethal 3 homolog (Drosophila)
IDBP-482531
male-specific lethal 3 homolog (Drosophila)
IDBP-482747
male-specific lethal 3 homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:11758159-11775753
Strand Forward strand
Band p22.2
Transcripts
ENST00000312196 ENSP00000312244
ENST00000361672 ENSP00000354562
ENST00000337339 ENSP00000338078
ENST00000380693 ENSP00000370069
ENST00000380692 ENSP00000370068
ENST00000380691 ENSP00000370067
ENST00000398527 ENSP00000381538
ENST00000421368 ENSP00000401809
ENST00000468149 ENSP00000418673
ENST00000476743 ENSP00000419976
ENST00000478462
ENST00000482871
ENST00000473806
ENST00000483645
ENST00000494268
ENST00000467141
ENST00000473380
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0035064 methylated histone binding
Biological Process
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0043984 histone H4-K16 acetylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0072487 MSL complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031358
View Gene Order
ENSBTAG00000009278
Not yet available
Pathways
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8N5Y2
TrEMBL A6NLU8 B4E2T7 C9JKR8 F8WC61 H7BYE4
UniProt Splice Variant
Entrez Gene 10943
UniGene Hs.655288
RefSeq NM_001193270 NM_001282174 NM_006800 NM_078628 NM_078629 XM_005274440 XM_006724461
HUGO HGNC:7370
OMIM 300609
CCDS CCDS14147 CCDS14148 CCDS14149 CCDS55369 CCDS65213
HPRD
IMGT
EMBL AC004554 AF117065 AK025642 AK289780 AK294255 AK300814 AK304419 AL050178 AL713667 BC031210 CH471074
GenPept AAD38499 AAH31210 BAF82469 BAG62470 BAG65249 BAH11713 CAB43308 CAD28473 EAW98799 EAW98801
RNA Seq Atlas 10943

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca