Version 5.4
Bos taurus Gene: MSL3
Summary
InnateDB Gene IDBG-639322.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSL3
Gene Name male-specific lethal 3 homolog
Synonyms MSL3L1
Species Bos taurus
Ensembl Gene ENSBTAG00000009278
Encoded Proteins
IDBP-691474
male-specific lethal 3 homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005302:
This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:142041442-142056938
Strand Reverse strand
Band
Transcripts
ENSBTAT00000030541 ENSBTAP00000030520
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0035064 methylated histone binding
Biological Process
GO:0043984 histone H4-K16 acetylation
Cellular Component
GO:0005634 nucleus
GO:0072487 MSL complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000005302
View Gene Order
ENSMUSG00000031358
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_218274
Chromatin organization pathway
REACT_226917
HATs acetylate histones pathway
REACT_202766
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BFW0
UniProt Splice Variant
Entrez Gene 515220
UniGene Bt.102584 Bt.109646 Bt.64696
RefSeq NM_001192404 XM_005197508 XM_005202774
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02075489
GenPept
RNA Seq Atlas 507494 515220

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca