Homo sapiens Gene: GABRA5
Summary
InnateDB Gene IDBG-4400.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRA5
Gene Name gamma-aminobutyric acid (GABA) A receptor, alpha 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186297
Encoded Proteins
gamma-aminobutyric acid (GABA) A receptor, alpha 5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:26866363-26949207
Strand Forward strand
Band q12
Transcripts
ENST00000335625 ENSP00000335592
ENST00000355395 ENSP00000347557
ENST00000400081 ENSP00000382953
ENST00000555182 ENSP00000450653
ENST00000557484
ENST00000554038 ENSP00000451527
ENST00000554596 ENSP00000450806
ENST00000557449
ENST00000555060 ENSP00000450932
ENST00000554599 ENSP00000450717
ENST00000554083 ENSP00000450529
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004890 GABA-A receptor activity
GO:0005215 transporter activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
GO:0050811 GABA receptor binding
Biological Process
GO:0001662 behavioral fear response
GO:0006810 transport
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0007165 signal transduction
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 synaptic transmission
GO:0007420 brain development
GO:0007605 sensory perception of sound
GO:0008306 associative learning
GO:0034220 ion transmembrane transport
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0048666 neuron development
GO:0055085 transmembrane transport
GO:0060119 inner ear receptor cell development
GO:0060384 innervation
GO:0090102 cochlea development
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0032809 neuronal cell body membrane
GO:0034707 chloride channel complex
GO:0043235 receptor complex
GO:0044297 cell body
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Ligand-gated ion channel transport pathway
Neuronal System pathway
GABA receptor activation pathway
Orphan transporters pathway
Ion channel transport pathway
Transmission across Chemical Synapses pathway
GABA A receptor activation pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
Gamma-aminobutyric acid receptor life cycle pathway [Biocarta view]
Cardiac protection against ros [Biocarta view]
PID NCI
Cross-References
SwissProt P31644
TrEMBL B4E1A2 G3V296 G3V2G8 G3V2K2 G3V2Q9 G3V408
UniProt Splice Variant
Entrez Gene 2558
UniGene
RefSeq NM_000810 NM_001165037 XM_005268258 XM_006720459
HUGO HGNC:4079
OMIM 137142
CCDS CCDS45194
HPRD
IMGT
EMBL AC127511 AC135999 AC145167 AC145196 AF061785 AF228447 AF228448 AF228449 AK290453 AK303742 BC111979 BC113422 BT009830 CH471151 EU606048 L08485
GenPept AAA58490 AAC31809 AAF62508 AAF62509 AAF62510 AAI11980 AAI13423 AAP88832 BAF83142 BAG64714 EAW57656 EAW57657
RNA Seq Atlas 2558