Version 5.4
Homo sapiens Gene: SH3RF1
Summary
InnateDB Gene IDBG-44101.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3RF1
Gene Name SH3 domain containing ring finger 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154447
Encoded Proteins
IDBP-44103
SH3 domain containing ring finger 1
IDBP-478839
SH3 domain containing ring finger 1
IDBP-480728
SH3 domain containing ring finger 1
IDBP-478178
SH3 domain containing ring finger 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:169094256-169271105
Strand Reverse strand
Band q33
Transcripts
ENST00000284637 ENSP00000284637
ENST00000511421 ENSP00000426418
ENST00000508685
ENST00000502315 ENSP00000427585
ENST00000510806 ENSP00000421714
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0016567 protein ubiquitination
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046328 regulation of JNK cascade
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0030027 lamellipodium
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031642
View Gene Order
ENSBTAG00000001508
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 57630
UniGene Hs.593881
RefSeq NM_020870
HUGO HGNC:17650
OMIM
CCDS CCDS34099
HPRD 15335
IMGT
EMBL
GenPept
RNA Seq Atlas 57630

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca