Homo sapiens Gene: SH3RF1
Summary
InnateDB Gene IDBG-44101.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3RF1
Gene Name SH3 domain containing ring finger 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154447
Encoded Proteins
SH3 domain containing ring finger 1
SH3 domain containing ring finger 1
SH3 domain containing ring finger 1
SH3 domain containing ring finger 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:169094256-169271105
Strand Reverse strand
Band q33
Transcripts
ENST00000284637 ENSP00000284637
ENST00000511421 ENSP00000426418
ENST00000508685
ENST00000502315 ENSP00000427585
ENST00000510806 ENSP00000421714
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0016567 protein ubiquitination
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046328 regulation of JNK cascade
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0030027 lamellipodium
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.593881
RefSeq NM_020870
HUGO
OMIM
CCDS CCDS34099
HPRD 15335
IMGT
EMBL
GenPept
RNA Seq Atlas