Version 5.4
Mus musculus Gene: Sh3rf1
Summary
InnateDB Gene IDBG-157099.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh3rf1
Gene Name SH3 domain containing ring finger 1
Synonyms 2200003J05Rik; Posh; R75531; Sh3md2
Species Mus musculus
Ensembl Gene ENSMUSG00000031642
Encoded Proteins
IDBP-157101
SH3 domain containing ring finger 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154447:
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:61224171-61396072
Strand Forward strand
Band B3.1
Transcripts
ENSMUST00000034060 ENSMUSP00000034060
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046328 regulation of JNK cascade
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154447
View Gene Order
ENSBTAG00000001508
Not yet available
Cross-References
SwissProt
TrEMBL E9QQ33
UniProt Splice Variant
Entrez Gene 59009
UniGene Mm.27949 Mm.409109
RefSeq NM_021506
OMIM
CCDS CCDS40348
HPRD
IMGT
MGI ID MGI:1913066
MGI Symbol Sh3rf1
EMBL AC117196 AC134339
GenPept
RNA Seq Atlas 59009

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca