Version 5.4
Homo sapiens Gene: TCF7
Summary
InnateDB Gene IDBG-44412.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCF7
Gene Name transcription factor 7 (T-cell specific, HMG-box)
Synonyms TCF-1
Species Homo sapiens
Ensembl Gene ENSG00000081059
Encoded Proteins
IDBP-44416
transcription factor 7 (T-cell specific, HMG-box)
IDBP-44426
transcription factor 7 (T-cell specific, HMG-box)
IDBP-240365
transcription factor 7 (T-cell specific, HMG-box)
IDBP-240367
transcription factor 7 (T-cell specific, HMG-box)
IDBP-474363
transcription factor 7 (T-cell specific, HMG-box)
IDBP-476466
transcription factor 7 (T-cell specific, HMG-box)
IDBP-474075
transcription factor 7 (T-cell specific, HMG-box)
IDBP-474248
transcription factor 7 (T-cell specific, HMG-box)
IDBP-480872
transcription factor 7 (T-cell specific, HMG-box)
IDBP-484034
transcription factor 7 (T-cell specific, HMG-box)
IDBP-483644
transcription factor 7 (T-cell specific, HMG-box)
IDBP-479190
transcription factor 7 (T-cell specific, HMG-box)
IDBP-473801
transcription factor 7 (T-cell specific, HMG-box)
IDBP-478968
transcription factor 7 (T-cell specific, HMG-box)
IDBP-474614
transcription factor 7 (T-cell specific, HMG-box)
IDBP-477627
transcription factor 7 (T-cell specific, HMG-box)
IDBP-484113
transcription factor 7 (T-cell specific, HMG-box)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:134114711-134151865
Strand Forward strand
Band q31.1
Transcripts
ENST00000342854 ENSP00000340347
ENST00000378560 ENSP00000367822
ENST00000395029 ENSP00000378472
ENST00000395023 ENSP00000378469
ENST00000518887 ENSP00000430617
ENST00000522653
ENST00000517851 ENSP00000429946
ENST00000521639 ENSP00000427782
ENST00000522375 ENSP00000427870
ENST00000520958 ENSP00000429547
ENST00000518915 ENSP00000430179
ENST00000519447 ENSP00000431095
ENST00000517741 ENSP00000427758
ENST00000519165
ENST00000520652 ENSP00000429817
ENST00000519037 ENSP00000429696
ENST00000521970
ENST00000517478
ENST00000522561
ENST00000524342
ENST00000519238
ENST00000517855 ENSP00000429178
ENST00000517799 ENSP00000427968
ENST00000520699 ENSP00000429935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 7 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006955 immune response
GO:0007420 brain development
GO:0016055 Wnt signaling pathway
GO:0021915 neural tube development
GO:0030538 embryonic genitalia morphogenesis
GO:0033153 T cell receptor V(D)J recombination
GO:0042127 regulation of cell proliferation
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0046632 alpha-beta T cell differentiation
GO:0048557 embryonic digestive tract morphogenesis
GO:0048619 embryonic hindgut morphogenesis
GO:0048699 generation of neurons
GO:0060070 canonical Wnt signaling pathway
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000782
View Gene Order
ENSBTAG00000001002
Not yet available
Pathways
NETPATH
REACTOME
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_200799
binding of TCF/LEF:CTNNB1 to target gene promoters pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_172761
Ca2+ pathway pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_111102
Signal Transduction pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228106
repression of WNT target genes pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
KEGG
hsa05221
Acute myeloid leukemia pathway
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa05216
Thyroid cancer pathway
hsa04520
Adherens junction pathway
hsa05213
Endometrial cancer pathway
hsa05215
Prostate cancer pathway
hsa05217
Basal cell carcinoma pathway
hsa04916
Melanogenesis pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.608171 Hs.688155
RefSeq NM_001134851 NM_003202 NM_201632 NM_201634 NM_213648 XM_006714684 XM_006714685
HUGO
OMIM
CCDS CCDS4169 CCDS4170 CCDS43362 CCDS47263
HPRD 01797
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca