Version 5.4
Homo sapiens Gene: XPOT
Summary
InnateDB Gene IDBG-44894.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XPOT
Gene Name exportin, tRNA
Synonyms XPO3;
Species Homo sapiens
Ensembl Gene ENSG00000184575
Encoded Proteins
IDBP-44896
exportin, tRNA (nuclear export receptor for tRNAs)
IDBP-227054
exportin, tRNA (nuclear export receptor for tRNAs)
IDBP-598737
exportin, tRNA (nuclear export receptor for tRNAs)
IDBP-595527
exportin, tRNA (nuclear export receptor for tRNAs)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:64404350-64451127
Strand Forward strand
Band q14.2
Transcripts
ENST00000332707 ENSP00000327821
ENST00000400935 ENSP00000383722
ENST00000540203 ENSP00000441376
ENST00000542958
ENST00000538086 ENSP00000444345
ENST00000541842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0005488 binding
GO:0008536 Ran GTPase binding
Biological Process
GO:0006409 tRNA export from nucleus
GO:0006886 intracellular protein transport
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000034667
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000026962
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O43592
TrEMBL F5GYW6 F8WDU6
UniProt Splice Variant
Entrez Gene 11260
UniGene Hs.592579 Hs.617380 Hs.634570 Hs.735621 Hs.85951
RefSeq NM_007235
HUGO HGNC:12826
OMIM 603180
CCDS CCDS31852
HPRD 04418
IMGT
EMBL AC135279 AF039022 BC000950 BC020569 Y16414
GenPept AAC39793 AAH00950 AAH20569 CAA76202
RNA Seq Atlas 11260

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca