InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: XPOT

Summary

InnateDB Protein

IDBP-44896.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XPOT

Protein Name

exportin, tRNA (nuclear export receptor for tRNAs)

Synonyms

XPO3;

Species

Homo sapiens

Ensembl Protein

ENSP00000327821

InnateDB Gene

IDBG-44894 (XPOT)

Protein Structure

UniProt Annotation

Function

Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269PubMed:12138183, ECO:0000269PubMed:9512417, ECO:0000269PubMed:9660920}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.