Version 5.4
Homo sapiens Gene: CACNB1
Summary
InnateDB Gene IDBG-45318.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNB1
Gene Name calcium channel, voltage-dependent, beta 1 subunit
Synonyms CAB1; CACNLB1; CCHLB1
Species Homo sapiens
Ensembl Gene ENSG00000067191
Encoded Proteins
IDBP-45322
calcium channel, voltage-dependent, beta 1 subunit
IDBP-241837
calcium channel, voltage-dependent, beta 1 subunit
IDBP-241839
calcium channel, voltage-dependent, beta 1 subunit
IDBP-812939
calcium channel, voltage-dependent, beta 1 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:39173456-39197703
Strand Reverse strand
Band q12
Transcripts
ENST00000344140 ENSP00000345461
ENST00000394310 ENSP00000377847
ENST00000394303 ENSP00000377840
ENST00000492737
ENST00000539338
ENST00000536613
ENST00000577582
ENST00000582877
ENST00000582544
ENST00000577926
ENST00000582414
ENST00000622445 ENSP00000477612
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0008331 high voltage-gated calcium channel activity
Biological Process
GO:0006612 protein targeting to membrane
GO:0006810 transport
GO:0006816 calcium ion transport
GO:0007411 axon guidance
GO:0034765 regulation of ion transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005891 voltage-gated calcium channel complex
GO:0016529 sarcoplasmic reticulum
GO:0030315 T-tubule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020882
View Gene Order
ENSBTAG00000002036
Not yet available
Pathways
NETPATH
REACTOME
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_13685
Neuronal System pathway
REACT_18266
Axon guidance pathway
REACT_13606
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt Q02641
TrEMBL Q6TME4
UniProt Splice Variant
Entrez Gene 782
UniGene Hs.635
RefSeq NM_000723 NM_199247 NM_199248 XM_005257646 XM_005257647
HUGO HGNC:1401
OMIM 114207
CCDS CCDS11334 CCDS42311 CCDS45665
HPRD
IMGT
EMBL AB054985 AK289729 AY393857 BC037311 CH471152 L06110 L06111 L06112 M76560 M92301 M92302 M92303 U86952 U86953 U86954 U86955 U86956 U86957 U86958 U86959 U86960 U86961 Z21725 Z21726
GenPept AAA35631 AAA35632 AAA35633 AAA36167 AAA36168 AAA36169 AAA51894 AAB58779 AAB58780 AAB58781 AAH37311 AAQ97605 BAB21444 BAF82418 CAA79824 CAA79825 EAW60562
RNA Seq Atlas 782

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca