Version 5.4
Homo sapiens Protein: CACNB1
Summary
InnateDB Protein IDBP-241837.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNB1
Protein Name calcium channel, voltage-dependent, beta 1 subunit
Synonyms CAB1; CACNLB1; CCHLB1;
Species Homo sapiens
Ensembl Protein ENSP00000377847
InnateDB Gene IDBG-45318 (CACNB1)
Protein Structure
UniProt Annotation
Function The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Subcellular Localization Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Disease Associations
Tissue Specificity Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle. {ECO:0000269PubMed:8107964}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0007411 axon guidance
GO:0034765 regulation of ion transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005891 voltage-gated calcium channel complex
Protein Structure and Domains
PDB ID
InterPro IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
IPR001452 SH3 domain
IPR005443 Voltage-dependent calcium channel, L-type, beta-1 subunit
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF12052
PF00018
PF14604
PF00625
PRINTS PR01626
PR00452
PR01627
PIRSF
SMART SM00326
SM00072
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q02641
PhosphoSite PhosphoSite-Q02641
TrEMBL
UniProt Splice Variant
Entrez Gene 782
UniGene Hs.635
RefSeq NP_954856
HUGO HGNC:1401
OMIM 114207
CCDS CCDS45665
HPRD 11743
IMGT
EMBL AB054985 AK289729 BC037311 CH471152 L06110 L06111 L06112 M76560 M92301 M92302 M92303 U86952 U86953 U86954 U86955 U86956 U86957 U86958 U86959 U86960 U86961 Z21725 Z21726
GenPept AAA35631 AAA35632 AAA35633 AAA36167 AAA36168 AAA36169 AAA51894 AAB58779 AAB58780 AAB58781 AAH37311 BAB21444 BAF82418 CAA79824 CAA79825 EAW60562

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca