Homo sapiens Gene: VEGFC
Summary
InnateDB Gene IDBG-45463.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VEGFC
Gene Name vascular endothelial growth factor C
Synonyms Flt4-L; LMPH1D; VRP;
Species Homo sapiens
Ensembl Gene ENSG00000150630
Encoded Proteins
vascular endothelial growth factor C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
FLT4 signalling represents a negative feedback mechanism by immune cells to overreacting during bacterial infection; ligation of FLT4 by VEGFC reduces TLR4-triggered production of proinflammatory cytokines in macrophages.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Flt4 signalling represents a negative feedback mechanism by immune cells to overreacting during bacterial infection; ligation of Flt4 by Vegfc reduces TLR4-triggered production of proinflammatory cytokines in macrophages.
Entrez Gene
Summary The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:176683538-176792727
Strand Reverse strand
Band q34.3
Transcripts
ENST00000507638
ENST00000618562 ENSP00000480043
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042056 chemoattractant activity
GO:0043185 vascular endothelial growth factor receptor 3 binding
Biological Process
GO:0001525 angiogenesis
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002052 positive regulation of neuroblast proliferation
GO:0002576 platelet degranulation
GO:0006929 substrate-dependent cell migration
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0016331 morphogenesis of embryonic epithelium
GO:0030168 platelet activation
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031954 positive regulation of protein autophosphorylation
GO:0042493 response to drug
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0045776 negative regulation of blood pressure
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:0051781 positive regulation of cell division
GO:0060754 positive regulation of mast cell chemotaxis
GO:1901492 positive regulation of lymphangiogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0031093 platelet alpha granule lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
VEGF ligand-receptor interactions pathway
Signaling by VEGF pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Response to elevated platelet cytosolic Ca2+ pathway
VEGF binds to VEGFR leading to receptor dimerization pathway
Hemostasis pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Focal adhesion pathway
Pathways in cancer pathway
INOH
GPCR signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
VEGF and VEGFR signaling network
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.435215
RefSeq NM_005429
HUGO
OMIM
CCDS CCDS43285
HPRD 03317
IMGT
EMBL
GenPept
RNA Seq Atlas