InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VEGFC

Summary

InnateDB Gene

IDBG-45463.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VEGFC

Gene Name

vascular endothelial growth factor C

Synonyms

Flt4-L; LMPH1D; VRP

Species

Homo sapiens

Ensembl Gene

ENSG00000150630

Encoded Proteins

IDBP-808734

vascular endothelial growth factor C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24656836

FLT4 signalling represents a negative feedback mechanism by immune cells to overreacting during bacterial infection; ligation of FLT4 by VEGFC reduces TLR4-triggered production of proinflammatory cytokines in macrophages.

InnateDB Annotation from Orthologs

Summary

PMID 24656836

[Mus musculus] Flt4 signalling represents a negative feedback mechanism by immune cells to overreacting during bacterial infection; ligation of Flt4 by Vegfc reduces TLR4-triggered production of proinflammatory cytokines in macrophages.

Entrez Gene

Summary

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:176683538-176792727

Strand

Reverse strand

Band

q34.3

Transcripts

ENST00000507638
ENST00000618562	ENSP00000480043

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042056	chemoattractant activity
GO:0043185	vascular endothelial growth factor receptor 3 binding

Biological Process

GO:0001525	angiogenesis
GO:0001954	positive regulation of cell-matrix adhesion
GO:0002052	positive regulation of neuroblast proliferation
GO:0002576	platelet degranulation
GO:0006929	substrate-dependent cell migration
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0016331	morphogenesis of embryonic epithelium
GO:0030168	platelet activation
GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031954	positive regulation of protein autophosphorylation
GO:0042493	response to drug
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0045776	negative regulation of blood pressure
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050714	positive regulation of protein secretion
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0050930	induction of positive chemotaxis
GO:0051781	positive regulation of cell division
GO:0060754	positive regulation of mast cell chemotaxis
GO:1901492	positive regulation of lymphangiogenesis