|Homo sapiens Gene: VEGFC|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||vascular endothelial growth factor C|
|Synonyms||Flt4-L; LMPH1D; VRP;|
vascular endothelial growth factor C
|Useful resources||Stemformatics EHFPI ImmGen|
FLT4 signalling represents a negative feedback mechanism by immune cells to overreacting during bacterial infection; ligation of FLT4 by VEGFC reduces TLR4-triggered production of proinflammatory cytokines in macrophages.
|InnateDB Annotation from Orthologs|
[Mus musculus] Flt4 signalling represents a negative feedback mechanism by immune cells to overreacting during bacterial infection; ligation of Flt4 by Vegfc reduces TLR4-triggered production of proinflammatory cytokines in macrophages.
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]
|Genomic Location||Chromosome 4:176683538-176792727|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
VEGF ligand-receptor interactions pathway
Signaling by VEGF pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Response to elevated platelet cytosolic Ca2+ pathway
VEGF binds to VEGFR leading to receptor dimerization pathway
Cytokine-cytokine receptor interaction pathway
Focal adhesion pathway
Pathways in cancer pathway
GPCR signaling pathway
VEGF signaling pathway pathway
VEGF and VEGFR signaling network
Alpha9 beta1 integrin signaling events
|UniProt Splice Variant|
|RNA Seq Atlas|