Version 5.4
Homo sapiens Gene: NEIL3
Summary
InnateDB Gene IDBG-45522.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEIL3
Gene Name nei endonuclease VIII-like 3 (E. coli)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109674
Encoded Proteins
IDBP-45524
nei endonuclease VIII-like 3 (E. coli)
IDBP-480474
nei endonuclease VIII-like 3 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:177309836-177362943
Strand Forward strand
Band q34.3
Transcripts
ENST00000264596 ENSP00000264596
ENST00000513321 ENSP00000424735
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000405 bubble DNA binding
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006289 nucleotide-excision repair
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039396
View Gene Order
ENSBTAG00000005825
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt Q8TAT5
TrEMBL D6RAV1
UniProt Splice Variant
Entrez Gene 55247
UniGene Hs.405467
RefSeq NM_018248
HUGO HGNC:24573
OMIM 608934
CCDS CCDS3828
HPRD
IMGT
EMBL AB079071 AC027627 AK001720 BC025954 DQ310721
GenPept AAH25954 ABC40719 BAA91860 BAC06479
RNA Seq Atlas 55247

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca