Version 5.4
Homo sapiens Gene: CHMP2B
Summary
InnateDB Gene IDBG-45704.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHMP2B
Gene Name charged multivesicular body protein 2B
Synonyms ALS17; CHMP2.5; DMT1; VPS2-2; VPS2B
Species Homo sapiens
Ensembl Gene ENSG00000083937
Encoded Proteins
IDBP-45706
charged multivesicular body protein 2B
IDBP-477880
charged multivesicular body protein 2B
IDBP-477355
charged multivesicular body protein 2B
IDBP-808604
charged multivesicular body protein 2B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:87227271-87255548
Strand Forward strand
Band p11.2
Transcripts
ENST00000263780 ENSP00000263780
ENST00000471660 ENSP00000419998
ENST00000494980 ENSP00000418920
ENST00000472024 ENSP00000480032
ENST00000466696
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0007034 vacuolar transport
GO:0008219 cell death
GO:0015031 protein transport
GO:0016032 viral process
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0061024 membrane organization
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004843
View Gene Order
ENSBTAG00000007939
Not yet available
Pathways
NETPATH
REACTOME
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_27258
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_6359
Budding and maturation of HIV virion pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 25978
UniGene
RefSeq NM_001244644 NM_014043
HUGO HGNC:24537
OMIM 609512
CCDS CCDS2918 CCDS58840
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 25978

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca