InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CHMP2B

Summary

InnateDB Gene

IDBG-630723.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHMP2B

Gene Name

Charged multivesicular body protein 2b

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007939

Encoded Proteins

IDBP-682201

Charged multivesicular body protein 2b

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000083937:
This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:34970460-35004356

Strand

Forward strand

Band

Transcripts

ENSBTAT00000010436

ENSBTAP00000010436

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006810	transport
GO:0007034	vacuolar transport
GO:0015031	protein transport

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005768	endosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome