Homo sapiens Gene: DCTD
Summary
InnateDB Gene IDBG-45729.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCTD
Gene Name dCMP deaminase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000129187
Encoded Proteins
dCMP deaminase
dCMP deaminase
dCMP deaminase
dCMP deaminase
dCMP deaminase
dCMP deaminase
dCMP deaminase
dCMP deaminase
dCMP deaminase
dCMP deaminase
dCMP deaminase
dCMP deaminase
dCMP deaminase
dCMP deaminase
dCMP deaminase
dCMP deaminase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:182890060-182917936
Strand Reverse strand
Band q35.1
Transcripts
ENST00000357067 ENSP00000349576
ENST00000438320 ENSP00000398194
ENST00000500813 ENSP00000425462
ENST00000507543 ENSP00000422386
ENST00000507631 ENSP00000425287
ENST00000510370 ENSP00000424017
ENST00000503182 ENSP00000422662
ENST00000510307 ENSP00000424050
ENST00000512766 ENSP00000423182
ENST00000514754 ENSP00000423894
ENST00000513383
ENST00000513348 ENSP00000425904
ENST00000503820 ENSP00000421792
ENST00000509757 ENSP00000423498
ENST00000509218 ENSP00000427470
ENST00000503988 ENSP00000422729
ENST00000508994 ENSP00000427282
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004132 dCMP deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Biological Process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0008152 metabolic process
GO:0009165 nucleotide biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046134 pyrimidine nucleoside biosynthetic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Pyrimidine metabolism pathway
Metabolism of nucleotides pathway
Metabolism pathway
Pyrimidine biosynthesis pathway
KEGG
Pyrimidine metabolism pathway
INOH
Pyrimidine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D6R9P0
UniProt Splice Variant
Entrez Gene 1635
UniGene Hs.183850 Hs.594177 Hs.736502
RefSeq NM_001012732 NM_001921 XM_005262778 XM_005262779 XM_005262780 XM_005262781 XM_005262782 XM_006714113 XM_006714114 XM_006714115 XM_006714116
HUGO HGNC:2710
OMIM 607638
CCDS CCDS34108 CCDS3831
HPRD 09623
IMGT
EMBL AC079766
GenPept
RNA Seq Atlas 1635