Version 5.4
Homo sapiens Gene: PPP1R1B
Summary
InnateDB Gene IDBG-45759.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R1B
Gene Name protein phosphatase 1, regulatory (inhibitor) subunit 1B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131771
Encoded Proteins
IDBP-45761
protein phosphatase 1, regulatory (inhibitor) subunit 1B
IDBP-241928
protein phosphatase 1, regulatory (inhibitor) subunit 1B
IDBP-241930
protein phosphatase 1, regulatory (inhibitor) subunit 1B
IDBP-760640
IDBP-760945
IDBP-760775
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:39626740-39636626
Strand Forward strand
Band q12
Transcripts
ENST00000254079 ENSP00000254079
ENST00000394267 ENSP00000377810
ENST00000394265 ENSP00000377808
ENST00000492037
ENST00000580825 ENSP00000462137
ENST00000580772
ENST00000582680 ENSP00000462522
ENST00000580029
ENST00000579000 ENSP00000462841
ENST00000583446
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004860 protein kinase inhibitor activity
GO:0004864 protein phosphatase inhibitor activity
GO:0008599 protein phosphatase type 1 regulator activity
GO:0031748 D1 dopamine receptor binding
GO:0031749 D2 dopamine receptor binding
GO:0031750 D3 dopamine receptor binding
GO:0031751 D4 dopamine receptor binding
GO:0031752 D5 dopamine receptor binding
Biological Process
GO:0001975 response to amphetamine
GO:0006351 transcription, DNA-templated
GO:0006469 negative regulation of protein kinase activity
GO:0007165 signal transduction
GO:0007621 negative regulation of female receptivity
GO:0008542 visual learning
GO:0035556 intracellular signal transduction
GO:0043086 negative regulation of catalytic activity
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061718
View Gene Order
ENSBTAG00000006035
Not yet available
Pathways
NETPATH
NetPath_8
Wnt pathway
NetPath_23
TSH pathway
REACTOME
REACT_15334
DARPP-32 events pathway
REACT_15295
Opioid Signalling pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.286192
RefSeq NM_001242464 NM_032192 NM_181505 XM_006722137
HUGO
OMIM
CCDS CCDS11339 CCDS11340
HPRD 05097
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca