InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PPP1R1B

Summary

InnateDB Gene

IDBG-45759.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1R1B

Gene Name

protein phosphatase 1, regulatory (inhibitor) subunit 1B

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000131771

Encoded Proteins

IDBP-45761

protein phosphatase 1, regulatory (inhibitor) subunit 1B

IDBP-241928

protein phosphatase 1, regulatory (inhibitor) subunit 1B

IDBP-241930

protein phosphatase 1, regulatory (inhibitor) subunit 1B

IDBP-760640

IDBP-760945

IDBP-760775

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:39626740-39636626

Strand

Forward strand

Band

q12

Transcripts

ENST00000254079	ENSP00000254079
ENST00000394267	ENSP00000377810
ENST00000394265	ENSP00000377808
ENST00000492037
ENST00000580825	ENSP00000462137
ENST00000580772
ENST00000582680	ENSP00000462522
ENST00000580029
ENST00000579000	ENSP00000462841
ENST00000583446

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0004864	protein phosphatase inhibitor activity
GO:0008599	protein phosphatase type 1 regulator activity
GO:0031748	D1 dopamine receptor binding
GO:0031749	D2 dopamine receptor binding
GO:0031750	D3 dopamine receptor binding
GO:0031751	D4 dopamine receptor binding
GO:0031752	D5 dopamine receptor binding

Biological Process

GO:0001975	response to amphetamine
GO:0006351	transcription, DNA-templated
GO:0006469	negative regulation of protein kinase activity
GO:0007165	signal transduction
GO:0007621	negative regulation of female receptivity
GO:0008542	visual learning
GO:0035556	intracellular signal transduction
GO:0043086	negative regulation of catalytic activity
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0043025	neuronal cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000061718

View Gene Order

ENSBTAG00000006035

Not yet available

Pathways

NETPATH

NetPath_8

Wnt pathway

NetPath_23

TSH pathway

REACTOME

REACT_15334

DARPP-32 events pathway

REACT_15295

Opioid Signalling pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.286192

RefSeq

NM_001242464 NM_032192 NM_181505 XM_006722137

HUGO

OMIM

CCDS

CCDS11339 CCDS11340

HPRD

05097

IMGT

EMBL

GenPept

RNA Seq Atlas