InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IFNG

Summary

InnateDB Gene

IDBG-45916.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFNG

Gene Name

interferon, gamma

Synonyms

IFG; IFI

Species

Homo sapiens

Ensembl Gene

ENSG00000111537

Encoded Proteins

IDBP-45918

interferon, gamma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20157607

The combined treatment of IFNG with 1,25-dihydroxyvitamin D3 (1,25-D3) synergistically enhances nitric oxide (NO) synthesis and NOS2 expression induced by Mycobacterium tuberculosis (MTB) or by its purified protein derivatives in human monocyte-derived macrophages.

PMID 20381453

IFNG mediates DUOX2 dual oxidase expression via a STAT-independent signalling pathway and providing insights into a novel IFNG signalling pathway with potential importance for regulation of host defence responses.

PMID 17981204

IFNG is crucial for immunity against intracellular pathogens and for tumour control and it is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response.

PMID 24012417

IFN gamma creates a primed chromatin environment in macrophages to augment TLR-induced gene transcription.

PMID 25474109

IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.

PMID 25732728

Primary γδ T cells provide an early source of IFNG during dengue virus (DV) infection and target DV-infected cells. Monocytes also participate as accessory cells that sense DV infection and amplify the cellular immune response in an IL18-dependent manner.

PMID 25637949

DEFB103A and RNASE7 are induced in human umbilical endothelial cells (HUVECs) by classical inflammatory cytokines such as: IFNG, IL1B and TNF.

PMID 26288256

IFNG primes mast cells for enhanced anti-bacterial and pro-inflammatory responses to Staphylococcus aureus, partially mediated by ITGB1.

Entrez Gene

Summary

This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:68154768-68159747

Strand

Reverse strand

Band

q15

Transcripts

ENST00000229135

ENSP00000229135

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	9 [view]
Protein-DNA	19 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005133	interferon-gamma receptor binding
GO:0005515	protein binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001781	neutrophil apoptotic process
GO:0002026	regulation of the force of heart contraction
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002250	adaptive immune response
GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response
GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006925	inflammatory cell apoptotic process
GO:0006928	cellular component movement
GO:0006955	immune response
GO:0006959	humoral immune response
GO:0007050	cell cycle arrest
GO:0007166	cell surface receptor signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0019882	antigen processing and presentation
GO:0030593	neutrophil chemotaxis
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031642	negative regulation of myelination
GO:0032224	positive regulation of synaptic transmission, cholinergic
GO:0032700	negative regulation of interleukin-17 production
GO:0032735	positive regulation of interleukin-12 production
GO:0032747	positive regulation of interleukin-23 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0034393	positive regulation of smooth muscle cell apoptotic process
GO:0042102	positive regulation of T cell proliferation
GO:0042493	response to drug
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042742	defense response to bacterium
GO:0042832	defense response to protozoan
GO:0044130	negative regulation of growth of symbiont in host
GO:0044146	negative regulation of growth of symbiont involved in interaction with host
GO:0045080	positive regulation of chemokine biosynthetic process
GO:0045084	positive regulation of interleukin-12 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045348	positive regulation of MHC class II biosynthetic process
GO:0045410	positive regulation of interleukin-6 biosynthetic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045666	positive regulation of neuron differentiation
GO:0045672	positive regulation of osteoclast differentiation
GO:0045785	positive regulation of cell adhesion
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050776	regulation of immune response
GO:0050796	regulation of insulin secretion
GO:0050954	sensory perception of mechanical stimulus
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0051607	defense response to virus
GO:0051712	positive regulation of killing of cells of other organism
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060550	positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
GO:0060552	positive regulation of fructose 1,6-bisphosphate metabolic process
GO:0060557	positive regulation of vitamin D biosynthetic process
GO:0060559	positive regulation of calcidiol 1-monooxygenase activity
GO:0071222	cellular response to lipopolysaccharide
GO:0071351	cellular response to interleukin-18
GO:0072308	negative regulation of metanephric nephron tubule epithelial cell differentiation
GO:0097191	extrinsic apoptotic signaling pathway
GO:0098908	regulation of neuronal action potential
GO:2000309	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2000345	regulation of hepatocyte proliferation